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Premature Release from Wurster Fluid Bed Enteric Coatings

Achieving reliable enteric coating with Wurster fluid bed processes can be a complex task, particularly when premature release occurs under acidic conditions where the polymer coat should remain intact. This whitepaper explores the underlying mechanisms that contribute to premature API release, providing a detailed analysis of factors such as coat permeability, coat thickness, and particle attrition. Whether you’re encountering issues related to coat integrity or looking to refine your enteric coating processes, this resource offers valuable insights that will guide you toward more consistent results.

What You Will Learn:

• Understanding Coat Permeability and Premature Release: Learn how permeability impacts enteric coating performance and discover the factors contributing to early API release, including the role of coat thickness and material characteristics.
• Addressing Particle Attrition and Coat Integrity:
  Gain insight into how particle attrition, surface irregularities, and accretion affect the quality and durability of enteric coatings, and explore strategies to mitigate these issues during the coating process.
• Optimizing Equipment Design and Process Conditions: Explore the importance of fluidization dynamics, air distribution, and nozzle configurations in Wurster fluid bed systems, and how optimal equipment design can minimize premature release and enhance coating efficiency.